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A rapid method to determine proliferation patterns of normal and malignant tissues by H3 mRNA in situ hybridization.

A general method applicable for the determination of any mammalian tissue's proliferative pattern is described. This method determines the cellular mRNA level of a proliferation-dependent gene, histone H3, by in situ hybridization. The cell-cycle S-phase-specific expression of this highly conse...

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Autori principali: Chou, M. Y., Chang, A. L., McBride, J., Donoff, B., Gallagher, G. T., Wong, D. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1877650/
https://ncbi.nlm.nih.gov/pubmed/2327469
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