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Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene

A hallmark of tumorigenesis is resistance to apoptosis. To explore whether resistance to cell death precedes tumor formation, we have studied the short-term effects of the hepatocarcinogen 2-acetylaminofluorene (AAF) on liver mitochondria, on hepatocytes, and on the response to bacterial endotoxin l...

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Detalhes bibliográficos
Main Authors: Klöhn, Peter-Christian, Soriano, Maria Eugenia, Irwin, William, Penzo, Daniele, Scorrano, Luca, Bitsch, Annette, Neumann, Hans-Günter, Bernardi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC187745/
https://ncbi.nlm.nih.gov/pubmed/12907702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633614100
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