Molecular basis of rifampin resistance in Mycobacterium leprae.

Rifampin is currently the most potent drug used in leprosy control programs. We show that the rifampin resistance which emerged in nine patients with lepromatous leprosy, who had received rifampin monotherapy, stemmed from mutations in the rpoB gene, which encodes the beta subunit of RNA polymerase...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Honore, N, Cole, S T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1993
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8460911/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.3.414
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