Search for Hsp90 Inhibitors with Potential Anticancer Activity: Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert

In an effort to discover small molecule inhibitors of Hsp90, we have screened over 500 EtOAc extracts of Sonoran desert plant-associated fungi using a two-stage strategy consisting of a primary cell-based heat shock induction assay (HSIA) followed by a secondary biochemical luciferase refolding assa...

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Auteurs principaux: Turbyville, Thomas J., Kithsiri Wijeratne, E. M., Liu, Manping X., Burns, Anna M., Seliga, Christopher J., Luevano, Libia A., David, Cynthia L., Faeth, Stanley H., Whitesell, Luke, Leslie Gunatilaka, A. A.
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876775/
https://ncbi.nlm.nih.gov/pubmed/16499313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np058095b
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