A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains

Two series of peptides that specifically bind to the extracellular domain of the α chain of the human interleukin-5 receptor (IL-5Rα), but share no primary sequence homology to IL-5, were identified from libraries of random recombinant peptides. Affinity maturation procedures generated a 19-aa pepti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	England, Bruce P., Balasubramanian, Palaniappan, Uings, Iain, Bethell, Sue, Chen, Min-Jia, Schatz, Peter J., Yin, Qun, Chen, Yao-Fen, Whitehorn, Erik A., Tsavaler, Alexander, Martens, Christine L., Barrett, Ronald W., McKinnon, Murray
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18766/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823900/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110053997
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