Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism

The dopamine transporter (DAT) is a target of amphetamine (AMPH) and cocaine. These psychostimulants attenuate DAT clearance efficiency, thereby increasing synaptic dopamine (DA) levels. Re-uptake rate is determined by the number of functional transporters at the cell surface as well as by their tur...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Saunders, Christine, Ferrer, Jasmine V., Shi, Lei, Chen, Jiayun, Merrill, Gerald, Lamb, Maria E., Leeb-Lundberg, L. M. Fredrik, Carvelli, Lucia, Javitch, Jonathan A., Galli, Aurelio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18764/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.110035297
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