Coumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent.

Coumermycin A1 is an inhibitor of DNA gyrase, an enzyme that catalyzes supercoiling of DNA and is required for bacterial DNA replication. We have investigated the activity of this coumarin antibiotic on Borrelia burgdorferi, a spirochete and the causative agent of Lyme disease. B. burgdorferi was mo...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Samuels, D S, Garon, C F
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1993
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC187602/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8381639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.1.46
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