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ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase
The intra-S-phase checkpoint in yeast responds to stalled replication forks by activating the ATM-like kinase Mec1 and the CHK2-related kinase Rad53, which in turn inhibit spindle elongation and late origin firing and lead to a stabilization of DNA polymerases at arrested forks. A mutation that dest...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC187497/ https://ncbi.nlm.nih.gov/pubmed/12502744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.239802 |
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