Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the ribosomal RNA (rRNA) gene copies, which are part of the nucleolus. Here we show that human cells lacking DNA methyltransferase 1 (Dnmt1), bu...

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Detalhes bibliográficos
Main Authors: Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F., Villar-Garea, Ana, Németh, Attila, Lopez-Serra, Lidia, Ropero, Santiago, Aranda, Agustin, Orozco, Helena, Moreno, Vanessa, Juarranz, Angeles, Stockert, Juan Carlos, Längst, Gernot, Grummt, Ingrid, Bickmore, Wendy, Esteller, Manel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874631/
https://ncbi.nlm.nih.gov/pubmed/17355984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm118
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