Nucleocapsid protein-mediated maturation of dimer initiation complex of full-length SL1 stemloop of HIV-1: sequence effects and mechanism of RNA refolding

Specific binding of HIV-1 viral protein NCp7 to a unique 35-base RNA stem-loop SL1 is critical for formation and packaging of the genomic RNA dimer found within HIV-1 virions. NCp7 binding stimulates refolding of SL1 from a metastable kissing dimer (KD) into thermodynamically stable linear dimer (LD...

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Detalhes bibliográficos
Main Authors: Mujeeb, Anwer, Ulyanov, Nikolai B., Georgantis, Stefanos, Smirnov, Ivan, Chung, Janet, Parslow, Tristram G., James, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874624/
https://ncbi.nlm.nih.gov/pubmed/17341460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm097
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