Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uracils reveal the basis for properties as antigene and antisense molecules

Oligonucleotides containing 5-(N-aminohexyl)carbamoyl-modified uracils have promising features for applications as antigene and antisense therapies. Relative to unmodified DNA, oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2′-deoxyuridine ((N)U) or 5-(N-aminohexyl)carbamoyl-2′-O-methyluridin...

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Bibliografske podrobnosti
Main Authors: Juan, Ella Czarina Magat, Kondo, Jiro, Kurihara, Takeshi, Ito, Takanori, Ueno, Yoshihito, Matsuda, Akira, Takénaka, Akio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874594/
https://ncbi.nlm.nih.gov/pubmed/17341465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl821
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