Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase

AIMS: Celecoxib is a novel selective cyclooxygenase-2 inhibitor, which is subject to extensive hepatic metabolism. The aims of the present in vitro investigation were 1) to compare the rate of celecoxib hydroxylation by different genetic variants of cytochrome P450 2C9 (CYP2C9), and 2) to identify t...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Sandberg, Mia, Yasar, Ümit, Strömberg, Patrik, Höög, Jan-Olov, Eliasson, Erik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2002
Konular:
Drug Disposition
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874434/
https://ncbi.nlm.nih.gov/pubmed/12392591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01660.x
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