Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5α-reductase inhibitor, in normal subjects treated with single or multiple doses

AIMS: To assess the tolerability, pharmacokinetics and pharmacodynamics of a novel nonsteroidal and noncompetitive inhibitor of type I and type II 5α-reductases, (–)-(S)-4-[1-[4-[1-(4-isobutylphenyl) butoxy]benzoyl]indolizin-3-yl]butyric acid (TF-505), after single and multiple oral doses in healthy...

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Detalhes bibliográficos
Main Authors: Fujita, Tomoe, Matsumoto, Yoshiaki, Kimura, Toshimi, Yokota, Shinichi, Sawada, Mika, Majima, Masataka, Ohtani, Yoshio, Kumagai, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Pharmacokinetics/Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874425/
https://ncbi.nlm.nih.gov/pubmed/12236849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2002.01656.x
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