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Are altered pharmacokinetics of non-steroidal anti-inflammatory drugs (NSAIDs) a risk factor for gastrointestinal bleeding?

AIMS: We hypothesised that pharmacokinetic factors might go some way to explaining the risk of major gastrointestinal haemorrhage with non-steroidal anti-inflammatory drugs (NSAIDs), with bleeders exhibiting a reduced clearance of NSAIDs compared with non-bleeders and set out to investigate this. ME...

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Detalhes bibliográficos
Main Authors: Wynne, H A, Long, A, Nicholson, E, Ward, A, Keir, D
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873969/
https://ncbi.nlm.nih.gov/pubmed/9578191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00696.x
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