Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

AIMS: Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by CYP3A4, the effect of grapefruit juice, an inhibitor of CYP3A4, was investigated on its bioavailability. METHODS: After an overnight fast, eight h...

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Main Authors: Kupferschmidt, Hugo H T, Fattinger, Karin E, Ha, Huy Riem, Follath, Ferenc, Krähenbühl, Stephan
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 1998
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873963/
https://ncbi.nlm.nih.gov/pubmed/9578182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00687.x
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