Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

AIMS: Saquinavir is a potent HIV protease inhibitor whose effectiveness is limited in vivo by its low bioavailability. Since saquinavir is metabolized by CYP3A4, the effect of grapefruit juice, an inhibitor of CYP3A4, was investigated on its bioavailability. METHODS: After an overnight fast, eight h...

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Bibliografiska uppgifter
Huvudupphovsmän: Kupferschmidt, Hugo H T, Fattinger, Karin E, Ha, Huy Riem, Follath, Ferenc, Krähenbühl, Stephan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 1998
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873963/
https://ncbi.nlm.nih.gov/pubmed/9578182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.t01-1-00687.x
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