Cytotoxic Necrotizing Factor 1 of Escherichia coli Stimulates Rho/Rho-Kinase-Dependent Myosin Light-Chain Phosphorylation without Inactivating Myosin Light-Chain Phosphatase in Endothelial Cells

Cytotoxic necrotizing factor 1 (CNF-1) is an exotoxin of Escherichia coli that constitutively activates the GTPases Rho, Rac, and CDC42. Stimulation of Rho was shown to enhance myosin light-chain (MLC) phosphorylation via Rho kinase-mediated inhibition of MLC phosphatase in endothelial cells. Here w...

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Autors principals: Essler, Markus, Linder, Stefan, Schell, Barbara, Hüfner, Katharina, Wiedemann, Agnès, Randhahn, Katharina, Staddon, James M., Aepfelbacher, Martin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC187342/
https://ncbi.nlm.nih.gov/pubmed/12933863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.9.5188-5193.2003
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