Gut wall metabolism of verapamil in older people: effects of rifampicin-mediated enzyme induction

AIMS: To investigate prehepatic metabolism of verapamil and its inducibility by rifampicin in older subjects. METHODS: Eight older subjects (67.1±1.2 years mean±s.d.) received racemic, unlabelled verapamil orally for 16 days (120 mg twice daily). Rifampicin (600 mg daily) was coadministered from day...

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Hlavní autoři: Fromm, Martin F, Dilger, Karin, Busse, Dagmar, Kroemer, Heyo K, Eichelbaum, Michel, Klotz, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 1998
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1873368/
https://ncbi.nlm.nih.gov/pubmed/9517368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1998.00669.x
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