O(6)-Benzylguanine suppression of O(6)-alkylguanine-DNA alkyltransferase in anaplastic gliomas

The purpose of the study was to determine the dose of O(6)-benzylguanine (BG) that would suppress O(6)-alkylguanine-DNA alkyltransferase (AGT) activity to undetectable levels in >90% of anaplastic gliomas, as measured 6 h after a 1-h BG infusion. Subjects who were scheduled for surgical resection...

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Detalhes bibliográficos
Main Authors: Schold, S. Clifford, Kokkinakis, Demetrius M., Chang, Susan M., Berger, Mitchel S., Hess, Kenneth R., Schiff, David, Robins, H. Ian, Mehta, Minesh P., Fink, Karen L., Davis, R.L., Prados, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Duke University Press 2004
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871964/
https://ncbi.nlm.nih.gov/pubmed/14769137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/S115285170300019X
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