Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains

We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized their component phenotypes. Sle1 mediates the loss of tolerance to nuclear antigens; Sle2 lowers the activation threshold of B...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Morel, Laurence, Croker, Byron P., Blenman, Kim R., Mohan, Chandra, Huang, Guanling, Gilkeson, Gary, Wakeland, Edward K.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18697/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.12.6670
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