DEOXYHYPUSINE HYDROXYLASE IS A Fe(II)-DEPENDENT, HEAT-REPEAT ENZYME: IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR Fe(II) BINDING AND CATALYSIS

Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine] in eIF5A. DOHH is a HEAT-repeat protein with eight tandem helical hairpins in a symmetrical dyad. It contains two potential iron coordination sites (one on...

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Bibliografiska uppgifter
Huvudupphovsmän: Kim, Yeon Sook, Kang, Kee Ryeon, Wolff, Edith C., Bell, Jessica K., McPhie, Peter, Park, Myung Hee
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868894/
https://ncbi.nlm.nih.gov/pubmed/16533814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M601081200
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