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Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP–inhibitor complexes are internalized via LRP

FSAP (Factor VII-activating protease) can inhibit neointima formation and VSMC (vascular smooth-muscle cell) proliferation by cleavage of PDGF-BB (platelet-derived growth factor-BB). Negatively charged polyanions lead to autoactivation of the FSAP, but no information is available concerning the pote...

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Библиографические подробности
Главные авторы: Muhl, Lars, Nykjaer, Anders, Wygrecka, Malgorzata, Monard, Denis, Preissner, Klaus T., Kanse, Sandip M.
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868796/
https://ncbi.nlm.nih.gov/pubmed/17298300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061630
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