Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis

Activation of the transcription factor NF-κB/Rel has been shown to be involved in inflammatory disease. Here we studied the role of RelA/p65, the main transactivating subunit, during acute pancreatitis using a Cre-loxP strategy. Selective truncation of the rela gene in pancreatic exocrine cells led...

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Detalhes bibliográficos
Main Authors: Algül, Hana, Treiber, Matthias, Lesina, Marina, Nakhai, Hassan, Saur, Dieter, Geisler, Fabian, Pfeifer, Alexander, Paxian, Stephan, Schmid, Roland M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868784/
https://ncbi.nlm.nih.gov/pubmed/17525802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29882
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