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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

We have developed a simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s). In this procedure, recombination requires the phage λ Red recombinase, which is synthesized under the control of an inducible pro...

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Hlavní autoři: Datsenko, Kirill A., Wanner, Barry L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC18686/
https://ncbi.nlm.nih.gov/pubmed/10829079
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