Efficient Elimination of Inhaled Nanoparticles from the Alveolar Region: Evidence for Interstitial Uptake and Subsequent Reentrainment onto Airways Epithelium

BACKGROUND: There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation. OBJECTIVES AND METHODS: We studied the disappearance of NPs from the epithelium by sequential lung retention and clearance and...

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Hauptverfasser: Semmler-Behnke, Manuela, Takenaka, Shinji, Fertsch, Steffanie, Wenk, Alexander, Seitz, Jürgen, Mayer, Paula, Oberdörster, Günter, Kreyling, Wolfgang G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2007
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867986/
https://ncbi.nlm.nih.gov/pubmed/17520060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.9685
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