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JAK2 V617F in Myeloid Disorders: Molecular Diagnostic Techniques and Their Clinical Utility : A Paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology
In early 2005, several groups of investigators studying myeloid malignancies described a novel somatic point mutation (V617F) in the conserved autoinhibitory pseudokinase domain of the Janus kinase 2 (JAK2) protein, which plays an important role in normal hematopoietic growth factor signaling. The V...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1867618/ https://ncbi.nlm.nih.gov/pubmed/16931578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2006.060007 |
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