Normal Remodeling of the Oxygen-Injured Lung Requires the Cyclin-Dependent Kinase Inhibitor p21(Cip1/WAF1/Sdi1)

Alveolar cells of the lung are injured and killed when exposed to elevated levels of inspired oxygen. Damaged tissue architecture and pulmonary function is restored during recovery in room air as endothelial and type II epithelial cells proliferate. Although excessive fibroblast proliferation and in...

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Main Authors: Staversky, Rhonda J., Watkins, Richard H., Wright, Terry W., Hernady, Eric, LoMonaco, Michael B., D’Angio, Carl T., Williams, Jacqueline P., Maniscalco, William M., O’Reilly, Michael A.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2002
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867303/
https://ncbi.nlm.nih.gov/pubmed/12368211
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