Blockade of Platelet-Derived Growth Factor or Its Receptors Transiently Delays but Does Not Prevent Fibrous Cap Formation in ApoE Null Mice

Platelet-derived growth factor (PDGF) is a potent stimulant of smooth muscle cell migration and proliferation in culture. To test the role of PDGF in the accumulation of smooth muscle cells in vivo, we evaluated ApoE −/− mice that develop complex lesions of atherosclerosis. Fetal liver cells from PD...

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Detalhes bibliográficos
Main Authors: Kozaki, Koichi, Kaminski, Wolfgang E., Tang, Jingjing, Hollenbach, Stan, Lindahl, Per, Sullivan, Carol, Yu, Jin-Chen, Abe, Keith, Martin, Paul J., Ross, Russell, Betsholtz, Christer, Giese, Neill A., Raines, Elaine W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867295/
https://ncbi.nlm.nih.gov/pubmed/12368212
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