The Nucleophosmin-Anaplastic Lymphoma Kinase Fusion Protein Induces c-Myc Expression in Pediatric Anaplastic Large Cell Lymphomas

The majority of pediatric anaplastic large cell lymphomas (ALCLs) carry the t(2;5)(p23;q35) chromosomal translocation that juxtaposes the dimerization domain of nucleophosmin with anaplastic lymphoma kinase (ALK). The nucleophosmin-ALK fusion induces constitutive, ligand-independent activation of th...

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Bibliographic Details
Main Authors: Raetz, Elizabeth A., Perkins, Sherrie L., Carlson, Marlee A., Schooler, Kevin P., Carroll, William L., Virshup, David M.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867246/
https://ncbi.nlm.nih.gov/pubmed/12213716
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