Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits

Genome-wide linkage analysis using microsatellite markers has been successful in the identification of numerous Mendelian and complex disease loci. The recent availability of high-density single-nucleotide polymorphism (SNP) maps provides a potentially more powerful option. Using the simulated and C...

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Detalhes bibliográficos
Main Authors: Klein, Alison P, Tsai, Ya-Yu, Duggal, Priya, Gillanders, Elizabeth M, Barnhart, Michael, Mathias, Rasika A, Dusenberry, Ian P, Turiff, Amy, Chines, Peter S, Goldstein, Janet, Wojciechowski, Robert, Hening, Wayne, Pugh, Elizabeth W, Bailey-Wilson, Joan E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Proceedings
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866766/
https://ncbi.nlm.nih.gov/pubmed/16451629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-6-S1-S20
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