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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinas...

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Bibliografski detalji
Glavni autori: Littlepage, Laurie E., Ruderman, Joan V.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC186670/
https://ncbi.nlm.nih.gov/pubmed/12208850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1007302
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