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Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinas...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
-д хэвлэсэн:Genes Dev
Үндсэн зохиолчид: Littlepage, Laurie E., Ruderman, Joan V.
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Cold Spring Harbor Laboratory Press 2002
Нөхцлүүд:
Онлайн хандалт:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208850/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1007302
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