Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

The Notch family of cell surface receptors plays a key role in cell-fate determination and differentiation, functioning in a cell- and context-specific manner. In mammalian cells, Notch activation is generally thought to maintain stem cell potential and inhibit differentiation, thereby promoting car...

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Pubblicato in:	Genes Dev
Autori principali:	Talora, Claudio, Sgroi, Dennis C., Crum, Christopher P., Dotto, G. Paolo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2002
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.988902
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