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Characterization of a Replication-Competent, Integrase-Defective Human Immunodeficiency Virus (HIV)/Simian Virus 40 Chimera as a Powerful Tool for the Discovery and Validation of HIV Integrase Inhibitors

Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to inhibit human immunodeficiency virus (HIV) replication or primarily affect off-site targets. Here we develop and validate a replication-competent, simian virus 40-HIV integrase mutant...

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Bibliografiske detaljer
Main Authors: Daelemans, Dirk, Lu, Richard, De Clercq, Erik, Engelman, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866133/
https://ncbi.nlm.nih.gov/pubmed/17287285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02637-06
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