Antigenic and Mutational Analyses of Herpes Simplex Virus Glycoprotein B Reveal Four Functional Regions

Glycoprotein B (gB), along with gD, gH, and gL, is essential for herpes simplex virus (HSV) entry. The crystal structure of the gB ectodomain revealed it to be an elongated multidomain trimer. We generated and characterized a panel of 67 monoclonal antibodies (MAbs). Eleven of the MAbs had virus-neu...

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Huvudupphovsmän: Bender, Florent C., Samanta, Minu, Heldwein, Ekaterina E., de Leon, Manuel Ponce, Bilman, Elina, Lou, Huan, Whitbeck, J. Charles, Eisenberg, Roselyn J., Cohen, Gary H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
Ämnen:
Genome Replication and Regulation of Viral Gene Expression
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866100/
https://ncbi.nlm.nih.gov/pubmed/17267495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02710-06
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