Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Critical for Ebola Virus Replication in Nonhuman Primates

Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are...

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Main Authors: Neumann, Gabriele, Geisbert, Thomas W., Ebihara, Hideki, Geisbert, Joan B., Daddario-DiCaprio, Kathleen M., Feldmann, Heinz, Kawaoka, Yoshihiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866002/
https://ncbi.nlm.nih.gov/pubmed/17229700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02486-06
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