Resistance to Pseudomonas aeruginosa Chronic Lung Infection Requires Cystic Fibrosis Transmembrane Conductance Regulator-Modulated Interleukin-1 (IL-1) Release and Signaling through the IL-1 Receptor

Innate immunity is critical for clearing Pseudomonas aeruginosa from the lungs. In response to P. aeruginosa infection, a central transcriptional regulator of innate immunity—NF-κB—is translocated within 15 min to the nuclei of respiratory epithelial cells expressing wild-type (WT) cystic fibrosis (...

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Main Authors: Reiniger, Nina, Lee, Martin M., Coleman, Fadie T., Ray, Christopher, Golan, David E., Pier, Gerald B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2007
Ábhair:
Host Response and Inflammation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865697/
https://ncbi.nlm.nih.gov/pubmed/17283089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01980-06
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