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The Two NK-1 Binding Sites Correspond to Distinct, Independent, and Non-Interconvertible Receptor Conformational States As Confirmed by Plasmon-Waveguide Resonance Spectroscopy

Two nonstoichiometric ligand binding sites have been previously reported for the NK-1 receptor, with the use of classical methods (radioligand binding and second messenger assays). The most populated (major, NK-1M) binding site binds substance P (SP) and is related to the adenylyl cyclase pathway. T...

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Detalhes bibliográficos
Main Authors: Alves, Isabel D., Delaroche, Diane, Mouillac, Bernard, Salamon, Zdzislaw, Tollin, Gordon, Hruby, Victor J., Lavielle, Solange, Sagan, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865500/
https://ncbi.nlm.nih.gov/pubmed/16618119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052586d
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