Yin Yang 1 is a critical regulator of B-cell development

The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain (IgH) locus and a block in the progenitor-B-to-precursor-B-cell transition,...

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Detalhes bibliográficos
Main Authors: Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, Pelanda, Roberta, Reth, Michael, Skok, Jane, Rajewsky, Klaus, Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865490/
https://ncbi.nlm.nih.gov/pubmed/17504937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1529307
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