Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-study

BACKGROUND: Pragmatic randomised controlled trials are often used in primary care to evaluate the effect of a treatment strategy. In these trials it is difficult to achieve both high internal validity and high generalisability. This article will discuss several methodological challenges in designing...

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Main Authors: Fransen, Gerdine AJ, van Marrewijk, Corine J, Mujakovic, Suhreta, Muris, Jean WM, Laheij, Robert JF, Numans, Mattijs E, de Wit, Niek J, Samsom, Melvin, Jansen, Jan BMJ, Knottnerus, J André
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865384/
https://ncbi.nlm.nih.gov/pubmed/17451599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-7-16
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