Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.

Reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has been achieved in transgenic mice expressing the HPV16 early-region genes, including the E6/E7 oncogenes, under the control of the human keratin-14 promoter/enhancer. Although 100% of K14-HPV16 transgenic animals...

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Bibliographic Details
Main Authors: Coussens, L. M., Hanahan, D., Arbeit, J. M.
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865365/
https://ncbi.nlm.nih.gov/pubmed/8952526
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