Interactions of Kid–Kis toxin–antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid–Kis oligomers

The parD operon of Escherichia coli plasmid R1 encodes a toxin–antitoxin system, which is involved in plasmid stabilization. The toxin Kid inhibits cell growth by RNA degradation and its action is neutralized by the formation of a tight complex with the antitoxin Kis. A fascinating but poorly unders...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Monti, Maria C., Hernández-Arriaga, Ana M., Kamphuis, Monique B., López-Villarejo, Juan, Heck, Albert J. R., Boelens, Rolf, Díaz-Orejas, Ramón, van den Heuvel, Robert H. H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2007
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865072/
https://ncbi.nlm.nih.gov/pubmed/17317682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm073
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