Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques

Cre is widely used for DNA tailoring and, in combination with recombineering techniques, to modify BAC/PAC sequences for generating transgenic animals. However, mammalian genomes contain recombinase recognition sites (cryptic loxP sites) that can promote illegitimate DNA recombination and damage whe...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Semprini, S., Troup, T.J., Kotelevtseva, N., King, K., Davis, J.R.E., Mullins, L.J., Chapman, K.E., Dunbar, D.R., Mullins, J.J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865043/
https://ncbi.nlm.nih.gov/pubmed/17284462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1108
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker