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Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

BACKGROUND: The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis elegans, lin-35, has only limited effects on viability and fertility, yet causes changes in cell-fate and cell-cycl...

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Hlavní autoři: Ceron, Julian, Rual, Jean-François, Chandra, Abha, Dupuy, Denis, Vidal, Marc, van den Heuvel, Sander
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1863419/
https://ncbi.nlm.nih.gov/pubmed/17417969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-7-30
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