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The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding
The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC186329/ https://ncbi.nlm.nih.gov/pubmed/11937491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.966402 |
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