Analysis of the S3 and S3′ subsite specificities of feline immunodeficiency virus (FIV) protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo

The S3 and S3′ subsite binding specificities of HIV and feline immunodeficiency virus proteases (FIV) proteases (PRs) have been explored by using C(2)-symmetric competitive inhibitors. The inhibitors evaluated contained (1S, 2R, 3R, 4S)-1,4-diamino-1,4-dibenzyl-2,3-diol as P1 and P1′ units, Val as P...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Lee, Taekyu, Laco, Gary S., Torbett, Bruce E., Fox, Howard S., Lerner, Danica L., Elder, John H., Wong, Chi-Huey
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1998
Gaiak:	Physical Sciences
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18632/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448264/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.939
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