Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase

HIV-1 reverse transcriptase (RT) catalyzes the conversion of genomic RNA into cDNA. The enzyme is a heterodimer of p66 and p51 subunits, and the dimerization of these subunits is required for optimal enzyme activity. To analyze this process at the genetic level, we developed constructs that permit t...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Tachedjian, Gilda, Aronson, Hans-Erik G., Goff, Stephen P.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 2000
Onderwerpen:	Biological Sciences
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18603/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841542/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.12.6334
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