Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

We have studied whether, or not, tissue-specific regulatory mechanisms provide normal 3,5,3'-triiodothyronine (T3) concentrations simultaneously in all tissues of a hypothyroid animal receiving thyroxine (T4), an assumption implicit in the replacement therapy of hypothyroid patients with T4 alone. T...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Escobar-Morreale, H F, Obregón, M J, Escobar del Rey, F, Morreale de Escobar, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118353
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