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Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module

The inability of certain N-linked glycoproteins to adopt their native conformation in the endoplasmic reticulum (ER) leads to their retrotranslocation into the cytosol and subsequent degradation by the proteasome. In this pathway the cytosolic peptide-N-glycanase (PNGase) cleaves the N-linked glycan...

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Autors principals: Zhou, Xiaoke, Zhao, Gang, Truglio, James J., Wang, Liqun, Li, Guangtao, Lennarz, William J., Schindelin, Hermann
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859912/
https://ncbi.nlm.nih.gov/pubmed/17088551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602954103
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