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Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

Lipoprotein lipase (LPL)-deficient mice have been created by gene targeting in embryonic stem cells. At birth, homozygous knockout pups have threefold higher triglycerides and sevenfold higher VLDL cholesterol levels than controls. When permitted to suckle, LPL-deficient mice become pale, then cyano...

Deskribapen osoa

Gorde:
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Weinstock, P H, Bisgaier, C L, Aalto-Setälä, K, Radner, H, Ramakrishnan, R, Levak-Frank, S, Essenburg, A D, Zechner, R, Breslow, J L
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 1995
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185959/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675619/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118319
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