Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes.

Lipoprotein lipase (LPL)-deficient mice have been created by gene targeting in embryonic stem cells. At birth, homozygous knockout pups have threefold higher triglycerides and sevenfold higher VLDL cholesterol levels than controls. When permitted to suckle, LPL-deficient mice become pale, then cyano...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Weinstock, P H, Bisgaier, C L, Aalto-Setälä, K, Radner, H, Ramakrishnan, R, Levak-Frank, S, Essenburg, A D, Zechner, R, Breslow, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185959/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675619/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118319
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