Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

Previous studies in vivo have shown that IL-10 infusion can prevent lethal endotoxic shock. Mice deficient in the production of IL-10 (IL10T) were used to investigate the regulatory role of IL-10 in the responses to LPS in three experimental systems. In a model of acute endotoxic shock, it was found...

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Pubblicato in:	J Clin Invest
Autori principali:	Berg, D J, Kühn, R, Rajewsky, K, Müller, W, Menon, S, Davidson, N, Grünig, G, Rennick, D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7593621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118290
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